{"id":12380,"date":"2022-05-11T20:53:23","date_gmt":"2022-05-11T12:53:23","guid":{"rendered":"http:\/\/www.gocpmall.com\/?p=12380"},"modified":"2022-05-11T20:53:23","modified_gmt":"2022-05-11T12:53:23","slug":"%e7%9c%9f%e5%ae%9e%e4%b8%96%e7%95%8c%e7%a0%94%e7%a9%b6%e6%8a%a5%e5%91%8a%ef%bc%9a%e7%96%ab%e8%8b%97%e6%b7%b7%e6%8e%a5%e6%88%96%e4%b8%ba%e6%9b%b4%e4%bc%98%e8%a7%a3","status":"publish","type":"post","link":"https:\/\/www.gocpmall.com\/?p=12380","title":{"rendered":"\u771f\u5b9e\u4e16\u754c\u7814\u7a76\u62a5\u544a\uff1a\u75ab\u82d7\u201c\u6df7\u63a5\u201d\u6216\u4e3a\u66f4\u4f18\u89e3"},"content":{"rendered":"

\"news
摘要： 随着新冠病毒持续变异，传染力大幅增强，全球多地新一轮疫情爆发后，有关疫苗接种选择的争论再次升温。其中，焦点性很强的一个议题是“是否要采用不同技术路线的疫苗进行加强接种”。2022年5月2日，北京大学谢晓亮组在bioRxiv上传了一篇评估3种新的Omicron亚型BA.2.12.1，BA.4和BA.5的免疫逃逸文章。 数据很翔实，这项研究尤其关注了国人应用最为广泛的灭活病毒疫苗全程接种为基础的加强\/感染后免疫应答；面对快速进化的突变株，优化接种策略势在必行。 目前较为常见的疫苗，有科兴疫苗（灭活）、复必泰疫苗（mRNA）等，近期香港大学公布了针对BNT162b2（复必泰）和CoronaVac（科兴）疫苗的多项实验数据。 在青少年（11到17岁）群体中，就体液免疫应答而言，2针mRNA疫苗的诱导效果高于2针灭活疫苗，比如S特异性IgG的对比数据是(GM OD450 0.54 vs 1.21；GMR 0.44, 95% CI 0.40-0.49)。 细胞免疫原应答上，CC组（灭活疫苗接种者）S 特异性IL-2+ CD4+T 细胞应答低于BB组（mRNA疫苗接种者）((0.015% vs 0.032%; GMR 0.45, 95% CI 0.28-0.72))。 此外，基于青少年NAb与VE间的关系推断疫苗预防有症状感染VE得出数据：2剂mRNA疫苗=93%; 2剂灭活疫苗=50%; 1剂mRNA疫苗=59%。可以看出，无论是1剂mRNA疫苗，还是2剂mRNA，保护力都要高于2剂灭活疫苗。 该研究还得出以下结论：第一，mRNA疫苗基础免疫程序诱导的S蛋白相关的各项抗体指标均高于2剂灭活疫苗；第二，2种疫苗完成基础2剂接种都能诱导较强的T细胞应答，其中mRNA疫苗诱导S特异性IL-2+ CD4+T细胞应答显著高于灭活疫苗。 在变异株免疫应答随时间变化的研究中，mRNA疫苗与灭活疫苗的表现也存在较大差距。就体液免疫来说，得出以下研究数据。 第一，mRNA疫苗组100% 疫苗接种者诱导了抗S蛋白lgG和抗RBD IgG，灭活疫苗组仅有85.7%。 第二，假病毒中和抗体反应发现，mRNA疫苗接种者血清对野生型的NAbTs比灭活疫苗接种者高 19 倍（图1b）。 而在细胞免疫维度，mRNA疫苗组产生针对VOCs的交叉NAb显著强于灭活疫苗组，前者中和抗体是后者的2.7-16倍（图2a）。 与港大类似，香港中文大学在对两种疫苗的免疫原性进行比较研究后得出以下实验数据。 第一，中和抗体检测 –替代病毒中和试验（sVNT）中，mRNA疫苗组数据是93.63%±7.92%，显著高于灭活疫苗组数据52.11%±22.06%（p 阅读更多，详细点击（Read More）<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

摘要： 随着新&#2089 […]<\/p>\n","protected":false},"author":1,"featured_media":12381,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[],"class_list":["post-12380","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-localnews"],"_links":{"self":[{"href":"https:\/\/www.gocpmall.com\/index.php?rest_route=\/wp\/v2\/posts\/12380","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.gocpmall.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.gocpmall.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.gocpmall.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.gocpmall.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=12380"}],"version-history":[{"count":0,"href":"https:\/\/www.gocpmall.com\/index.php?rest_route=\/wp\/v2\/posts\/12380\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.gocpmall.com\/index.php?rest_route=\/wp\/v2\/media\/12381"}],"wp:attachment":[{"href":"https:\/\/www.gocpmall.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=12380"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.gocpmall.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=12380"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.gocpmall.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=12380"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}